What are the opening hours?

Monday 8am - 9pm Tuesday 8am - 9pm Wednesday 8am - 9pm Thursday 8am - 9pm Friday 8am - 9pm Saturday 8am - 9pm Sunday 9am - 6pm

Lewis Drug

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Make your Sioux Falls Lewis your first stop!

Our conveniently located store at Minnesota Avenue & 37th Street offers a wide selection of everyday basics, plus name brands and specialty items, always at affordable prices. You'll find everything on your list along with a few unexpected finds in departments like Health & Beauty, Grocery, Pets, Wine & Spirits, Lawn & Garden and more.

11/02/2026

Lewis' annual Ladies Event is only 2 days away! Enjoy 20% off everything in-store* November 4–5. Plus, register on the Lewis App for a chance to win bonus app rewards

*Some exclusions apply.

11/01/2026

Lewis' annual Ladies Event is only 3 days away! Enjoy 20% off everything in-store* November 4–5. Plus, register on the Lewis App for a chance to win bonus app rewards

*Some exclusions apply.

10/31/2026

Lewis' annual Ladies Event is only 4 days away! Enjoy 20% off everything in-store* November 4–5. Plus, register on the Lewis App for a chance to win bonus app rewards

*Some exclusions apply.

10/30/2026

Lewis Pharmacy is now accepting Wellcare in 2027!

10/30/2026

Lewis' annual Ladies Event is only 5 days away! Enjoy 20% off everything in-store* November 4–5. Plus, register on the Lewis App for a chance to win bonus app rewards

*Some exclusions apply.

10/30/2026

Ladies Event is coming up quickly 💃 And we want to show you more of what will be there. You may already know you can get 20% off EVERYTHING*, but see more of what's in store during our annual Ladies Event on November 4 & 5.

*Some exclusions apply.

10/28/2026

The holiday kickoff is nearly here! 🤩🛒 November 4th & 5th will be here sooner than you think. Plan your shopping trip today, where you can save 20% off EVERYTHING*! Tell us what you're most excited to find during this year's Ladies Event.

*Exclusions apply.

Find the store nearest you so you can keep on saving.

10/28/2026

🎄 $100 LEWIS APP REWARD UP FOR GRABS! Show us your favorite outdoor Christmas displays for a chance to win a $100 Lewis App reward!

Snap a photo of your favorite outdoor Christmas display you've seen this year for a chance to win! We’ll randomly select one winner from all eligible entries across Facebook and Instagram. Giveaway ends November 3, and the winner will be contacted by direct message shortly after. No purchase necessary. This giveaway is not sponsored, endorsed, or administered by Meta.

And we wanted to lighten and up even more! Spend $100 or more on qualifying outdoor décor and get $15 off instantly with the Lewis App from October 28 through November 3.

10/28/2026

This Week’s Ad is Here
Find deals at Lewis from October 28th - November 3rd. View the full ad on our website or in the Lewis app.

Address

2901 S. Minnesota Avenue
Sioux Falls, SD
57105

Opening Hours

Monday	8am - 9pm
Tuesday	8am - 9pm
Wednesday	8am - 9pm
Thursday	8am - 9pm
Friday	8am - 9pm
Saturday	8am - 9pm
Sunday	9am - 6pm

Website

https://www.lewisdrug.com/stores/lewis-37th-minnesota-sioux-falls

Alerts

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