28/10/2026
HEALTH FOCUS: How does propolis affect the human gut microbiome?
Propolis is well known for its antimicrobial properties, and many of us ingest it on a daily basis. But what exactly happens when it reaches the gut? Does it suppress the beneficial bacteria living there along with potentially harmful microorganisms, or is the relationship more complex?
A 2022 study investigated this using human-derived gut microbiota. Researchers exposed microbiota from healthy adults and several groups of children to a standardised mixture of polyphenols extracted from poplar-type propolis following simulated digestion. What they found was not a general reduction in bacteria, but different responses among different bacterial populations.
In the healthy-adult microbiota, Oscillospira, Blautia and Lachnospira increased, while Bacteroides and Parabacteroides decreased. The response was different again in microbiota from children with obesity, where increases included Dialister, Subdoligranulum and Anaerostipes, and in microbiota from children with coeliac disease, where Bifidobacterium, Faecalibacterium and Fusicatenibacter increased.
These differing responses suggest that the effects of propolis polyphenols may depend, at least partly, on which microorganisms are already present in the gut microbial community. In other words, the introduction of propolis may produce different microbial changes in different microbiomes. This raises an interesting question for future research: could those different responses produce different, potentially beneficial effects?
The researchers also found that propolis affected what the microorganisms were producing. In the healthy-adult microbiota, fermentation with propolis polyphenols increased acetic acid by 119%, propionic acid by 832% and butyric acid by 142% compared with the blank fermentation. These are short-chain fatty acids produced by gut microorganisms, with established roles in intestinal physiology. They are involved in regulation of the intestinal barrier and immune responses, while butyrate provides an important source of energy for the cells lining the colon.
Research into propolis and the human gut microbiome is still at an early stage, and there is an important limitation here: this was an experimental study using human-derived gut microbiota, not a study in which people consumed propolis. We therefore cannot say that taking propolis will produce these same changes inside the human gut. What the research does show is that propolis polyphenols can influence both the composition and metabolic activity of human-derived gut microbial communities, providing good reason to investigate what those effects could mean for human gut health.
You can read more about the research and the fascinating relationship between propolis and both the honeybee and human gut microbiome at Hanna's Bees.